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References

Please note - this is not a medical site, nor do we intend to make any medical claims, but report on the usage of various ingredients in alternative and complimentary therapy - which should never be used instead of standard medical advise.

Statements on this site has not been evaluated by the US FDA or the SA MCC and no information contained on this site should be used to diagnose, treat, cure or prevent any disease.

But adhering to the directives of the FTC, we have included various references to ingredients and their actions.

If in doubt regarding a medical condition please contact your medical practitioner.

Adaptogens
Arginine
Bioflavonoids

Biotin

Chromium picolinate

Co-enzyme Q 10

Echinacea

Enzymes

Essential phospholipids

Ginger

Gingko biloba

Ginseng

Histidine

Goldenseal

Gotu Kola

Grape seed extract

Green tea

Licorice

Muira Puama
Selenium

St John's Wort

Vitamin A

Vitamin B1
Vitamin B5

Vitamin B6

Vitamin B12
Vitamin C

Vitamin E

Vitamin U
Zinc

Adaptogens

I. I. Brekhman, "What can oppose stress?" Adaptation and Adaptogens. Proceedings of the 2nd Symposium:" Processes of Adaptation and Biological Active Substances" (May 1975). Vladivostok: Far East Scientific Center of the Academy of Science of the USSR, 1977: 81.

I. I. Brekhman and I. V. Dardymov, "New Substances of Plant Origin which Increase Nonspecific Resistance" Annual Review of Pharmacology, 1969: v.9.

A. Panossian, G. Wikman and H. Wagner, "Plant adaptogens. New concepts on their mode of action." Phytomedicine, 6(4), 1-14, 1999.

Anisimov, M. M.; Fronert, E. B.; Froleva, G. M.; Suprunov, N. I.: Effect of glycosides of Eleuteroccocus senticosis on early embryogenesis of sea-urchin. Izy. Akad. Nauk SSSR Otd. Biol. Nauk, 4: 590–593, 1973.
Asaoka, Y.; Nakamura, S.; Yoshida, K.; Nishizuka, Y.: Protein kinase C, calcium and phospholipid degradation. TIBS. 17: 414–417, 1992.

Barnard, E. A.: Receptor classes and the transmitter-gated ion channels. TIBS 17: 368–274, 1992.

Bezdetko, G. N.; Brekhman, I. I.; Dardymov, I. V.; Zil’ber, M. L.; and Rogozkin, V. A.: Eleutherococcus glycosides effect on nuclear RNA polymerase activity in skeletal muscles and liver after physical strain“, J. Voprosy Med. Khimii, 19 (3): 245–248, 1973.

Bhattacharya, S. K.; Goel, R. K.; Kaur, R.; Ghosal S.: Antistress activity of Sitoindosides VII and VIII, New acylsterylblucosides from Withania somnifera. Phytotherapy research, 1 (1): 32–37, 1987.

Bowen, D. L.; Fauci, A. S.: Adrenal Corticosteroids. In: Inflammation. Basic principles and clinical correlates. Eds. J. I. Gallin, I. M. Goldstein, R. Snyderman. Raven Press, New York: 877–896, 1988.

Bredt, D. S.; Hwang, P. M.; Snyder, S. H.: Localization of nitric oxide synthase indicating a neural role for nitric oxide, Nature 347: 768–770, 1990.

Brekhman, I. I.: Eleuterococc, Nauka, Leningrad, 185 p., 1968 (rus.).

Brekhman, I. I.; Dardymov I. V.: New substances of plant origin which increase nonspecific resistance, Ann. Rev. Pharmacol. 8: 419–430, 1968.

Cambronero, J. C.; Rivas, F. J.; Borrell, J.; Guaza, C.: Role of  arachidonic acid metabolism on corticotropin releasing factor (CRF)-release induced by interleukin-1 from superfused rat hipothalami. J. Neuroimmunol. 39: 57–66, (1992).

Cannon, W. B.: Stresses and strains of homeostasis. Am. J. Med. Sci. 89: 1–14, 1935.

Chevallier, A.: The Encyclopedia of Medicinal Plants., Dorling Kindersley, London/New York/Stuttgart/Moscow, 1996, 336 p.

Chrousos, G. P.; Gold, P. W.: The consept of stress system disorders: overview of behavioral and physical homeostasis. JAMA 267: 1244–1252, 1992.

Cockroft, S.: G-protein-regulated phospholipases C.D and A2 mediated signaling in neutrophils. Biochim. Biophys. Acta. 1113: 135–160, 1992.

Clark, J. D.; Lin, L.-L.; Kritz, R. W.; Ramesha, C. S.; Sultzman, L. A.; Lin, A. Y.; Milona, N.; Knopf, J. L.: A novel arachidonic acid selective cytosolic PLA2 contains a Ca+2- dependent translocation domain with homology to PKC and GAP. Cell 65: 1043–1051, 1991.

Dardimov, I. V.: Ginzeng, eleuterococc. On the mechanism of biological activity, Nauka, Moscow. 184 p, 1976.

Dardymov, I. V.; Brekhman, I. I.: The influence of antimycin D on the regulation of carbohydrate metabolism, caused by Eleutherococcus glycosides and adrenal ectomy in rats, Materiali Itogovoj Naucknoy Sessii, VNIIFK, 1969.

Dardymov, I. V.; Bezdetko, G. N.; Brekhman I. I.: Incorporation of P32 into rat liver RNA under physical exercises and the effect of Eleutherococcus glycosides, Voprosy Med. Khimii, 18 (3): 267–269, 1972.

Dardymov, I. V.; Khasina, E. I.: The effect of Eleutherococcus glycosides on glucose uptake by rat diaphragm., In: Lek. Sredstva Dal’nego vostoka (Remedies of the Far East), The Institute of Biologically Active Substances of the USSR, Academy of Science, Vladivostok, Russia, 2: 52–55, 1972.

Dardymov, I. V.; Khasina E. I.: The effect of Ginseng and Eleutherococcus glycosides on hexokinase activity. In: Lek. Sredstva Dal’nego Vostoka (Remedies of the Far East), The Institute of Biologically Active Substances of the USSR, Academy of Science, Vladivostok, Russia, 2: 56–59, 1972.

Dardymov, I. V., Kirillov, O. I.: Mater XXII Nauk. Sesji, Khabarovsk Med. Inst., Khabarovsk, 1965.

Di Rosa, M.; Radomski, M.; Carnuccio, R.; Moncada, S.: Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. Biochem. Biophys. Res. Commun. 172: 1246–1252, 1990.

Durum, S. K., Schmidt, J. A., Opperheim, J. J.: Interleukin 1: an immunological perspective. Ann. Rev. Immunol 3: 263–287, 1985.

Elyakov, G. B.; Ovodov, Yu. S.: The glycosides of Araliaceae. Khimia Prirodnich Soedineniy (6): 697–709, 1972.

Evans, W. C.: Trease and Evans Pharmacognosy. WB Saunders Coompany Ltd, London–Philadelphia–Toronto –Sydnay–Tokio. 1996, 612 p.

FDA, 1998, Notice of Proposed Rulemaking, Federal Register, April 29, 1998a, Anon.

Flower, R. J.: The lipocortines and their role in controlling defence reactions. In: Adv. Prostagl. Thrombox. Leukotr. Res., Raven Press, New York, 15: 201–203, (1985).

Foegh, M. L., Ramwell, P. W.: Physiological implications of products in the arachidonic acid cascade. In: Prostaglandins and related substances, Elsevier Science Publishers B. V.: 13–19, (1983).

Friedman, E. M.; Irwin, M. R.: A role for CRH and the sympathetic immune system in stress-induced immunosuppression. in: Stress. Basic mechanisms and clinical implications. Eds. G. P. Chrousos, R. McCarty, K. Pacak, G. Cizza, E. Sternberg, P. W. Gold, R. Kventansky. Ann. NY Acad Sci. 771: 396–418, (1995).

Fulder, S.: The Drug that builds Russians, New Scientists, 21: pp. 83–84, 1980.

Ghosal, S.; Lal, J.; Srivatava, R.; Battacharya, R.; Upadhyay, S. N.; Jaiswal, A. K.; Chattopadhyay, U.: Anti-stress activity of Sitoindosides IX and X, New C-27-glycowithanolides from Withania somnifera Phytotherapy Res. 3 (5): 201–209, 1989.

Gold, P. W.; Goodwin, F.; Chrousos, G. P.: Clinical and biomedical manifestations of depression: relationship to theneurobiology of stress, Part 2. N. Engl. J. Med. 319: 413–420, 1988.

Goodwin, J. S.; Webb, D. R.: Regulation of immune response by prostaglandins. Clinical Dermatology and Immunopathology. 15: 106–122, 1980.

Hancke, J., Burgos, R.; Wikman, G.; Ewertz, E.; Ahumada, F.: Schizandra chinensis, a potential phytodrug for recovery of sport horses. Fitoterapia, 65 (2): 113–118, 1994.

Hancke, J.; Burgos, R.; Caceres, D.; Brunetti, F.; Durigon, A.; Wikman, G.: Reduction of serum hepatic transaminases and CPK in sport horses with poor performance treated with a standardized Schizandra chinensis fruit extract. Phytomedicine 3 (2): 237–240, 1996.

Helper, J.; Gilman, A.: G proteins, TIBS 17: 383–387, 1992. Hu, S. B.; Tannahill, L. A.; Lightman, S. L.: Interleukin-1 beta induces corticotropin releasing factor-41 release from cultured hypothalamic cells through proteinkinase C and cAMP-dependent protein kinase pathways. J. Neuroimmunol.40: 49–55, (1992).

Ip, S. P.; Poom, M. K. T.; Wu, S. S.; Che, C. T.; Ng, K. H.; Kong, Y. C.; Ko, K. M.: Effect on Schisandrin B on hepatic glutathione antioxidant system in mice: protection against carbon tetrachloride toxicity, Planta Medica., 61: 398 – 401, 1995.

Kopin, I. J.: Definitions of stress and sympathetic neuronal responses. In: Stress. Basic mechanisms and clinical implications. Eds. G. P. Chrousos, R. McCarty, K. Pacak, G. Cizza, E. Sternberg, P. W. Gold, R. Kventansky. Ann. NY Acad. Sci. 771: 1–18, 1995.

Kochetkov, N, K.; Khorlin, A. Y.; and Chizhov, O. S.; Sheichenko, V. I.: Chemical investigation of Schizandra Chinensis. Communication 2. Structure of Schizandrin, Izvestiyia Akademii Nauk SSSR, Seriya Khimicheskaya 5: 850–856, 1962.

Kurkin, V. A.; Zapesochnaya, G. G.: The Chemical Composition and Pharmacological Properties of Plants of the Genus Rhodiola (A Review), Khim. Farm. Zh., 20 (10): 1231– 1244, 1986.

Lazarev, N. V.: Actual problems of the studies of the action of adaptogens, particularly preparations of Eleuterococcus. Symposium on Ginzeng and Eleuterococcus. In: XX meeting on investigations of Ginseng and other medicinal plants of Far East, DVFSO, Vladivostok, 7–14, 1962.

Leonova, E. V.; Rodionova, T. V.: Effect of Eleutherococcus on Dynamics of Changes in Nucleic Acid and Protein Content in the Brain under the Effect of Ischemia, Vestsi Akad Nauk USSR Ser Biyal., 1: 93–96, 1979.

Li, S. E.: Effect of Eleutherosides on height and mitotic activity of the regenerating mouse liver, Bull. of Exp. Biol. and Medicine, 67 (6): 103–105, 1969.

Liu, G. T.; Zhang, T. M.; Wang, B. E.; Wang, Y. W.: ”Protective action of seven natural phenolic compounds against peroxidative damage to biomembranes“, Biochemical Pharmacology 43 (2): 147–152, 1992.

Lu, H.; Liu, G. T.: Effect of dibenzo-cycloctene lignans isolated from fructus Schizandrae on lipid peroxidation and antioxidative enzyme activity, Chem. Biol. Interactions, 78: 77–84, 1991.

Lu, H.; and Liu, G. T.: Anti-oxidant activity of dibenzocyclooctene lignans isolated from Schizandraceae, Planta Medica 58: 311–313, 1992.

Lupandin, A. V.; Lapaev, I. I.: Schizandra, Khabarovskoje Knizhnoye Izdatelstvo, Khabarovsk, 1–89, 1981.

Lupandin, A. V.: The role of catecholaminergic synapses in the mechanism of adaptation formation under the action of polyphenolic adaptogens. Sechenov, Physiological J. of USSR 75 (8): 1082–1088, 1989.

Lupandin, A. V.: General mechanism of adaption of the organism under the effect of polyphenol adaptogens Advances in Physiological Sciences. 22 (1): 1–40, 1991.

Malenkov, A. G., Kolotygina, I. M.: Cell surface RNA – A possible molecular receptor of adaptogens, Biofizika, 29 (5): 814–815, 1984.

Malyshev, I.; Prodius, P. A.; Arkhipenko, Yu. V.; Wikman, G.; Meerson, F. Z.: A new approach to studying the mechanism of action and searching for criteria of adaptogen activity. Proc. from the 5th World Congress, International Society for Adaptive Medicine, Poster Communication Session (III), 1997.

Meerson, F.: Adaptation, Stress and Prophylax, Nauka, Moscow, 1981, 278 p. (russ.); Springer-Verlag, 1984.

McCann, S. M.; Lyson, K.; Karanth, S.; Gimeno, M.; Belova, N.; Kamat, A.; Rettori, V.: Mechanism of action of cytokines to induce the pattern of pituitary hormone secretion in infection. In: Stress. Basic mechanisms and clinical implications. Eds. G. P. Chrousos, R. McCarty, K. Pacak, G. Cizza, E. Sternberg, P. W. Gold, R. Kventansky. Ann. NY Acad. Sci. 771: 626–639, 1995.

Moncada, S.; Higgs, A.: The L-arginine-nitric oxide pathway. New Engl. J. Med.: 2002–2012, 1993.

Munck, A.; Guyre, P. M.; Holbrook, N. J.: Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Rev. 5: 25–44, 1984.

Nakazato, Y.; Simonson, M. S.; Herman, W. H.; Konieczkowski, M.; Sedor, J. R.: Interleukin 1 stimulates prostaglandin biosynthesis in serum-activated mesangial cells by induction of a non-pancreatic (type II) phospholipase A2. J. Biol. Chem. 266: 14119–14127, 1991.

Nörr, H.: Phytochemical and pharmacological Investigations of the Adaptogens: Eleutherococcus senticosus, Ocimum sanctum, Codonopsis pilosula, Rhodiola rosea and Rhodiola crenulata, Ph. D. thesis, Faculty of Chemistry and Pharmacy, Ludwig-Maximilians University, München, 228 p., 1993.

Ohgo, S.; Nakatsuru, K.; Ishikawa, E.; Matsukura. S.: Inteleukin- 1 (IL-1) stimulates the Release of corticotropin releasing factor (CRF) from superfused rat hypothalamo-neurohypophyseal complexes (HNC) independently of the histaminergic mechanism. Brain Res. 558: 217–223, 1991.

Panossian, A.; Gabrielian, E.; Wagner, H.: Plant adaptogens II Bryonia as an adaptogen. Phytomedicine 4 (1): 83–97, 1997.

Panossian, A.; Oganessian, A.; Ambartsumian, M.; Gabrielian, E.; Wagner, H.; Wikman, G.: Effects of heavy physical exercise and adaptogens on nitric oxide content in human saliva, Phytomedicine 6 (1): 17–26, 1999.

Polukhina, N. N.; Kozlova, N. M.; Barenboim, G. M.; Chernitsky, E. A.: The effects of eleutheroside ”B” and a mixture of Eleutherococcus glycosides on glucose transport in erythrocytic membranes. New data on Eleutherococcus, Proc. of the 2nd Int’l Symposium on Eleutherococcus, Moscow, pp. 58–62, 1981.

Rand, M. J.: Nitrergic transmittion: nitric oxide as a media- Plant adaptogenes III 299 tor of non-adrenergic, non-cholinergic neuro-effector transmission. Clin. Exp. Pharmacol. Physiol. 19: 147–169,1992.

Rola-Pleszczynski, M.; Lamaire, I.: Leukortienes augments interleukin-1 production by human monocytes. J. Immunol.  135: 3958–3961, 1985.

Ssaratikov, A. S.; Krasnov, E. E., Chnikina, L. A.; Duvidson, L. M.; Sotova, M. I.; Marina, T. F.; Nechoda, M. F.; Aksenova, R. A.; Tschrdinzeff, S. G.: Rhodiolozid, ein neues Glykosid aus Rhodiola rosea und seine pharmakologischen Eigenschaften. Pharmazie 23: 392–395, 1968.

Saratikov, A. S.; Adamchuk, L. V.; Salnik, B. J.: Influence of Pipradrol and Rhodiola preparations on some indices of nucleic, protein and energetic metabolisms in the muscles of rats under the conditions of exhausting exercise. Izv-Sib- Otd-Akad-Nauk-Sssr-Ser-Biol-Med-Nauk. 2: 76–83, 1971.

Selye, H.: Stress. Acta Medical Publisher. Montreal, Quebec, Canada, 1950.

Sternberg, E. M.; Licinio, J.: Overview of neuroimmune stress interactions. In: Stress. Basic mechanisms and clinical implications. Eds. G. P. Chrousos, R. McCarty, K. Pacak, G. Cizza, E. Sternberg, P. W. Gold, R. Kventansky. Ann. NY Acad. Sci. 771: 364–371, 1995.

Stratakis, C. A.; Chrousos, G. F.: Neuroendocrinology and Pathophysiology of the Stress System. In: Stress. Basic mechanisms and clinical implications. Eds. G. P. Chrousos, R. McCarty, K. Pacak, G. Cizza, E. Sternberg, P. W. Gold, R. Kventansky. Ann. NY Acad Sci. 771: 1–18, 1995.

Tache, Y.; Rivier, C. (Eds): Corticotropine-releasing factor and cytokines: role in the stress response. Hans Selye symposium on neuroendocrinology and stress. Ann. NY Acad. Sci. 697: 1993.

Viru, A. A.: Hormonal mechanisms of adaptation and training. Nauka. Leningrad: 1981, 154 p.

Wagner, H.; Heur, Y. H.; Obermeier, A.; Tittel, G.; Bladt, S.: Die DC- and HPLC-Analyse der Eleutherococcus Droge, Journal of Medicinal Plant Research, 44: 193–198, 1982. Wagner, H.; Nörr, H.; Winterhoff, H.: Plant adaptogens. Phytomedicine 1: 63–76, 1994.

Wang, J. P.; Raung, S. L.; Hsu, M. F.; Chen, C. C.: Inhibition by gomisin C (a lignan from Schizandra chinensis) of the respiratory burst of rat neutrophils, Br. J. Pharmacol., 113: 945–953, 1994.

Zapesochnaya, G. G.; Kurkin, V. A.: Glycosides of cinnamyl alcohol from the rhizomes, Khimiya Prirodnykh Soedinenii (6): 723–727/685–688 (transl.), 1983.

Arginine

Lamm, M.D., Steven and Couzens, Gerald Secor, Younger at Last: The New World of Vitality Medicine (New York: 1997, Simon & Schuster), pages 62-64. ISBN 0-684-83438-3
Klatz, D.O., Ronald with Kahn, Carol, Grow Young with HGH (New York: 1997, HarperCollins Publishers, Inc.), pages 200, 201, 206, 304. ISBN 0-06-018682-8

Hendler, M.D., Ph.D., Sheldon Saul, The Doctor's Vitamin and Mineral Encyclopedia (New York: 1990, Fireside), pages 209-215. ISBN 0-671-66784-X
Quillin, Ph.D., R.D., Patrick, Healing Nutrients (New York: 1989, Vintage), pages 274, 368. ISBN 0-679-72187-8

Bioflavonoids

M. Calomme, et al., "Inhibition of Bacterial Mutagenesis by Citrus Flavonoids" Planta Med, 62(3), June 1996, p. 222-226.

A. Negre-Salvayre, et al., "Additional Antilipoperoxidant Activities of Alpha-tocopherol and Ascorbic Acid on Membrane-like Systems are Potentiated by Rutin," Pharmacology, 42(5), 1991, p. 262 - 272.

Biotin

L. G. Hochman, et al., "Brittle Nails: Response to Daily Biotin Supplementation," Cutis 51(4), April 1993, p. 303-305).

Chromium picolinate

R. A. Anderson, et al. "Chromium Supplementation of Human Subjects: Effects on Glucose, Insulin and Lipid Variables," Metabolism, 32 (9), September 1983, p. 894-899.

W. Mertz, et al., "Chromium in Human Nutrition: A Review," Journal of Nutrition, 123(4) April 1993, p.626-633.

Co-enzyme Q 10

K. Folkers and A. Wolaniuk, "Research on Coenzyme Q10 in Clinical Medicine and in Immunomodulation," Drug Exp Clin Res, 11(8), 1985, p. 539-545.

Echinacea

V. R. Bauer, et al., [Immunologic in Vivo and in Vitro Studies on Echinacea Extracts], Arzneimittelforschung, 38(2), February 1988, p. 276-281.

Enzymes

H. S. Mitchell, et al., "Nutrition in Health and Disease," Lippincott, 1976, p.124-155

Essential phospholipids

Mitchell et al., Nutrition in Health and Disease, 1976, p. 135.

Ginger

British Herbal Pharmacopoeia (BHP). 1996. Exeter, U.K.: British Herbal Medicine Association.

Gingko biloba

P. Koltringer, et al., [Hemorheologic Effect of Gingko Biloba Extract Egb 761. Dose-dependent Effect of Egb761 on Microcirculation and Viscoelasticity of Blood], Forstschr Med, 111(10) April 10, 1993, p.170-172.

Cohen, A.J. and B. Bartlik. 1998. Ginkgo Biloba for antidepressant-induced sexual dysfunction. J Sex Marital Ther 24(2):139–143. 
DeFeudis, F.V. 1998. Ginkgo biloba extract (EGb 761): From Chemistry to the Clinic. Weisbaden, Germany: Ullstein Medical Verlagsgesellschaft. 
Ernst, E. 1996. [Ginkgo biloba in treatment of intermittent claudication. A systematic research based on controlled studies in the literature] [In German]. Fortschr Med 114(8):85–87. 
Ernst, E. and M.H. Pittler. 1999. Ginkgo biloba Dementia: A systematic review of double-blind, placebo-controlled trials. Clin Drug Invest 17(4):301–308.
Gobbato, S., A. Griffini, E. Lolla, F. Peterlongo. 1996. HPLC quantitative analysis of biflavones in Ginkgo biloba leaf extracts and their identification by thermospray liquid chromatography-mass spectrometry. Fitoterapia 67(2):152–158. 

Ginseng

E. A. Sotaniemi, et al., "Ginseng Therapy in Non-Insulin-Dependent Diabetic Patients," Diabetic Care, 18(10), October 1995, p. 1373 - 1375.

V. D. Petkov, et al., "Effects of Standardized Ginseng Extract on Learning, Memory and Capabilities," American Journal of Chinese Medicine, 15(1), 1987, p.19-29.

H. K. Choi, et al., "Clinical Efficacy of Korean Red Ginseng for Erectile Dysfunction," International Journal of Impotence Research, 7(3), September 1995, p.181-186.

Histidine

L. G. Ignarro, Endothelium-derived nitric oxide: Actions and Properties, FASEB Journal, January 1989, 3(1):31-6.)

Goldenseal

D. Sun, et al., "Berberine Sulfate Blocks Adherence of Streptococcus pyogens to Epithelial Cells, Fibronectin and Hexadeceane," Antimicrobial Agents and Chemotheraphy, 32(9) September 1988, p. 1370 - 1374.

Gotu Kola

M. V. R. Appa Rao et al., The effect of mandookapami and punomovo for their rosayana effect on normal healthy adults, Nagarium, 120, 33-41, July 1969.

M. Weiner, Weiner's Herbal, Stein & Day, New York, 1980, 94 and C. Allegra et al., L'estralto di Centella asiatica nelle fiebopatie degli arti inferiori, Clinca Terapeutica, 99, 506-13, 1981)

Grape seed extract

Y. Rong, et al., "Pycnogenol Protects Vascular Endothelial Cells from t-butyl Hydroperoxide Induced Oxidant Injury," Biotechnol Ther, 5(3-4), 1994 - 1995, p. 117 - 26.

Green tea

B. L. Zhao, et al., "Scavenging Effects of Extracts of Green Tea and Natural Antioxidants on Active Oxygen Radicals", Cell Biophysics, 14(2), April 1989, p. 175-185.

S. Kono, et al., "Green Tea Consumption in Northern Kyushu, Japan" Prev Med, 21(4) July 1992, p. 526-531.

M. Serafini, et al., "In Vivo Antioxidant effect of Green and Black Tea in Man," European Journal of Clinical Nutrition, 50(1) January 1996, p. 28 - 32.

K. Imai & K. Nakachi, "Cross Sectional Study of Effects of Drinking Green Tea on Cardiovascular and liver diseases," British Medical Journal, 310 (6981), March 18, 1995, p. 693 - 696.

Licorice

R. Pompei, et al., "Glycyrrhizic Acid Inhibits Virus Growth and Inactivates Virus Particles", Nature, 281 (5733), October 25, 1979, p.689-690 and Bradley, P.R. (ed.). 1992. British Herbal Compendium, Vol. 1. Bournemouth: British Herbal Medicine Association.

Muira Puama 

Anselmino, Elisabeth. “Ancestral sources of Muira-puama.” Ach. Pharm. 1933; 271: 296–314.
Brazilian Pharmacopeia. “Muira puama. Ptychopetalum olacoides.” Rio de Janeiro, Brazil, 1956.
British Herbal Pharmacopoeia. “Muira puama.” West York, England: British Herbal Medicine Association, 1983; 132–33.
Youngken, H. W. “Observations on Muira puama.” J. Am. Pharm. Assoc. 1921; 10: 690–92.
Olofsson, Eric. “Action of extract of Liriosma ovata on the blood pressure, vessels and respiration of the rabbit.” Compt. Rend. Soc. Biol. 1927; 97: 1639-40.
Gaebler, H. “Revival of the drug Muira puama.” Deut. Apoth. 1979; 22(3): 94–6.
Dias Da Silva, Rodolpho. “Medicinal plants of Brazil. Botanical and pharmacognostic studies. Muira puama.” Rev. Bras. Med. Pharm. 1925; 1(1): 37–41.
Iwasa, J., et al. “Constituents of Muira puama.” Yakungaka Zasshi (Japan) 1969; 89(8): 1172–74.
Auterhoff, H., et al. “Components of Muira puama.” Arch. Pharm. Ber. Dtsch. Pharm. Ges. 1968; 301(7): 481–89.
Auterhoff, H., et al. “Components of Muira puama II.” Arch. Pharm. Ber. Dtsch. Pharm. Ges. 1969; 302(3): 209–12.
Auterhoff, H., et al. “Lipophilic constituents of Muira puama.” Arch. Pharm. Ber. Dtsch. Pharm. Ges. 1971; 304(3): 223–28.
Steinmetz, E. “Muira puama.” Quart. J. Crude Drug Res. 1971; 11(3): 1787–89.
Ninomiya, Ruriko, et al. “Studies of Brazilian crude drugs.” Shoyakugaku Zasshi (Japan) 1979; 33(2): 57–64.
Bucek, E., et al. “Volatile constituents of Ptychopetalum olacoides root oil.” Planta Med. 1989; 53(2): 231.
Penna, M. Notas Sobre Plantas Brasileriras. Rio de Janeiro: Araujo Penn & Cia., 1930, 258.
Waynberg, J. “Contributions to the clinical validation of the traditional use of Ptychopetalum guyanna.” Presented at the First International Congress on Ethnopharmacology, Strasbourg, France, June 5–9, 1990.
Waynberg, J. “Male sexual asthenia—interest in a traditional plant-derived medication.” Ethnopharmacology; 1995.
Hanawa., et al. “Composition containing an extract from Muira puama root and plant worm extract.” Taisho Pharmacuetical Co., Ltd., Tokyo, United States Patent No. 6024984, 2000.
Paiva, Laf, et al. “Effects of Ptychocepalum olacoides extract on mouse behaviour in forced swimming and open field tests.” Phytother. Res. 1998; 12(4): 294–96.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.
Elisabetsky, E., et al. Propriedades Psicofarmacologicas de Oleaceas, IX Simposio de Plantas Medicinais do Brazil, Rio de Janeiro, 1–3 September 1986, 32.
Asano, T., et al. “Oral compositions containing Muira purama for gastric mucosal lesions.” Japan Kokai Tokyo Hoho, Patent No. 11343244, 1999.
Vaz, Z. R., et al. “Analgesic effect of the herbal medicine Catuama in thermal and chemical models of nociception in mice.” Phytother. Res. 1997; 11(2): 101–6.
Cherksey, B. D. “Method of preparing Muira puama extract and its use for decreasing body fat percentage and increasing lean muscle mass.” United States Patent No. 5516516, 1996.
Forgacs, P., et al. “Phytochemical and biological activity studies on 18 plants from French Guyana.” Plant Med. Phytother. 1983; 17(1): 22–32.

Selenium

P. A. van den Brandt, et al., "A prospective Cohort Study of Selenium Status and the Risk of Lung Cancer" Cancer Research, 49 (11), June 1, 1989, p. 3020 - 3023.

M. Bonomini, et al., "Effects of Selenium Supplementation on Immune Parameters in Chronic Uraemic Patients on Haemodialysis," Neprol Dial Transplant, 10(9), 1995, p. 1654 - 1661.

St John's Wort

In this meta-analysis involving 23 randomized studies, 15 of which were placebo-controlled, it was found that hypericum extract proved significantly effective in the treatment of patients suffering from moderate to mildly severe depression.
(K. Linde, et al., "St John's Wort for Depression - an Overview and Meta-analysis of Randomized Clinical Trails," British Medical Journal, 313 (7052), August 3, 1996, p.253-258.)

In this study, an SHS-174 preparation, a lyophized infusion from flowers of Sambucus nigra L., aerial parts of Hypericum performatum L., and roots of Saponaria officinalis (100g, 70g, 40g) exhibited an antiherpes simplex virus type 1 effect in vitro. The preparation contains flavonoids, triperpene, saponins, phenolic acids, tannins and polysaccharide which could be responsible for its antiviral properties.
(J. Serkedjieva, et al., "Antiviral Activity of the Infusion (SHS-174) from Flowers of Sambucus Nigra L., Aerial Parts of Hypericum Perforatum, L, and Roots of Saponaria Offinalis L against Influenza and Herpes Simplex Viruses," Phytotherapy Research, 4(3), 1990, p.97-100.)

H. Muldner and M. Zoller, [Antidepressive Effect of a Hypericum Extract Standardized to an Active Hypericine Complex. Biochemical and Clinical Studies] Arzneimittelforschung, 34(8), 1984, p. 918-920.

Vitamin A

H. B. Stahelin, et al., "Beta-carotene and Cancer Prevention: The Basel Study." American Journal of Clinical Nutrition, 53(1 Suppl), January 1991, p. 265S - 269S.

G. van Poppel, et al., "Effect of Beta-carotene on Immunological Indexes in Healthy Male Smokers" American Journal of Clinical Nutrition, 57(3), March 1993, p.402-407.

Vitamin B1

M. Suzuki & Y. Itokawa, "Effects of Thiamine Supplementation on Exercised-induced Fatigue," Metabolic Pr Brain Dis, 11(1) March 1996, p.95-106.

Vitamin B5

H. S. Mitchell, et al. Nutrition in Health and Disease, Lippicott, 1976.

Vitamin B6

J. B. Deijen, et al., "Vitamin B-6 Supplementation in Elderly Men: Effects on Mood, Memory, Performance and Mental Effort," Psychopharmacology, 109(4), 1992, p. 489-496.

Vitamin B12

H. S. Mitchell, et al., "Nutrition in Health and Disease," Lippincott, 1976, p.106-108.

Vitamin C

Vitamin C, Cancer and Aging, Age, 16, 1993, p. 55-58.

H. Hemila, "Does Vitamin C Alleviate the Symptoms of the Common Cold?" - A Review of Current Evidence," Scandinavian Journal of Infectious Disease, 26(1), 1994, p.1-6.)

C. L. Phillips, et al. "Effects of Ascorbic Acid on Proliferation and Collagen Synthesis in Relation to the Donor age of Human Dermal Fibroblast," Journal of Investigative Dermatology, 103(2), August 1994, p.228-232.

E. Cheraskin, et al., "Daily Vitamin C Consumption and Fatigability," Journal of American Geriatric Society, 24(3), 1976, p.136-137.

G. E. Hatch, "Asthma, Inhaled Oxidants and Dietary Antioxidants," American Journal of Clinical Nutrition, 61(3 suppl) March 1995, p. 625S - 630S.)

C.F. Phillips, et al., "Effects of Ascorbic Acid on Proliferation and Collagen Synthesis in Realtion to the Donor Age of Human Dermal Fibroblast," Journal of Invest Dermatol 103(2) August 1994, p. 228 - 232)

W. M. Ringsdorf, Jr and E Cheraskin, "Vitamin C and Human Wound Healing" Oral Surg Oral Med Oral Pathol, 53(3), March 1982, p.231 - 236.

A. Negre-Salvayre, et al., "Additional Antilipoperoxidant Activities of Alpha-tocopherol and Ascorbic Acid on Membrane-like Systems are Potentiated by Rutin," Pharmacology, 42(5), 1991, p. 262 - 272.

Vitamin E

M. Passeri and D. Provvedini, [Vitamin E in Geriatric Physiopathology], Acta Vitaminol Enzymol, 5(1), 1983, p. 53-63.

F. Umeda, et al., "Effects of Vitamin E on Function of Pituitary-gonadal Axis in Male Rats and Human Subjects," Endocrinal Jpn, 29(3), June 1982, p.287-292.

E. Kessopoulou, et al., " A double blind rnadomized placebo controlled cross-over controlled trial using antioxidant Vitamin E to treat oxygen species associated male infertility." Fertil Steril, 64(4), October 1995, p. 825-831.

Vitamin U

Cheney G (1954). "Vitamin U concentrate therapy of peptic ulcer". American Journal of Gastroenterology 21 (3): 230-250. PMID 13138563. 

Cheney G (1955). "The medical management of gastric ulcers with vitamin U therapy". Stanford Med Bull 13 (2): 204-214. PMID 14386172. 

Cheney G, Waxler SH, Miller IJ (1956). "Vitamin U therapy of peptic ulcer; experience at San Quentin Prison". Calif Med 84 (1): 39-42. PMID 13276831. 

Cheney G (1952). "Vitamin U Therapy of Peptic Ulcer". California Medicine 77 (4): 248-252. PMID 13009468. 

Cheney G (1955). "The medical management of gastric ulcers with vitamin U therapy". Stanford Med Bull 13 (2): 204-214. PMID 14386172. 

Cheney G (1950). "The nature of the antipepticulcer dietary factor". Stanford Med Bull 8 (3): 144-161. PMID 14782068. 

Cheney G (1950). "Antipeptic ulcer dietary factor". American Dietetics Association 26 (9).

Zinc

G. Michaelson, et al., "Effects of Oral Zinc and Vitamin A on Acne", Arch Dermatol, 113(1), January 1977, p.31-36.)

A. A. Caldamone, et al., "Seminal Zinc and Male Infertility", Urology, 13(3), March 1979, p.280-281.

H. Takihara, et al., "Zinc Sulfate Therapy for Infertile Male with or without Varicocelectomy," Urology, 29(6) June 1987, p. 638-641.)

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