vitamins for a healthy vital energetic full dynamic life with zest for life vitamins
Since 1999 the most innovative vitamin supplement company
  • Kindly note that we are re-branding Zest for Life and that the new labels will be green - 
    replacing the silver labels we have had for 12 years - but this will be done on a systematic
    roll-out, and you will still receive vitamin products with silver labels for quite some time.

caucheteux approved quality

You can feel the vitamins work™
Michael Meyer


zest vitamins supplements

:: HOME
:: Contact us
 
 

ORDERING
Orders in U.S.A.
+ the rest of the world

:: Worldwide shipping
:: €,£,₯ etc converter
INTERNET SECURITY
Orders in South Africa
Bestellings in Suid Afrika

:: Aflewering
| Delivery
 
INFORMATION
 
:: Vitamin encyclopedia
:: Disease and nutrition
:: RDA
:: FREE diet
:: Search
:: Privacy
:: Copyright
:: Links

Astaxanthin reduces hypertension

This page looks at how astaxanthin helps with reducing high blood pressure when used as a dietary supplement, when used in the correct quantity.

astaxanthin reducing blood pressure anti-aging supplement pill capsule

on this page


Other pages of interest regarding the effect of astaxanthin:

© Fuji Health Science and various patents - clinical reference

General Astaxanthin reduces hypertension

Epidemiological and clinical data suggest that dietary carotenoids such as astaxanthin may protect against cardiovascular disease (CVD), which includes hypertension. This condition is associated with blood vessel dysfunction, altered contractility and tone; mediated by relaxant (nitric oxide NO; prostacyclin) and constrictor factors (thromboxane; endothelin) in the blood. Furthermore, blood flow properties serve an important role in the pathological complications seen in atherosclerosis and coronary heart disease. Research presented here suggests that astaxanthin may be useful as part of an antioxidant therapy to alleviate hypertension.

Reduction of Arterial Blood Pressure Astaxanthin reduces hypertension

An early study involving a composition of carotenoids have been used against hypertension or high blood pressure (BP), but Hussein et al., (2005a) published the first study involving astaxanthin with spontaneously hypertensive rats (SHR) and stroke prone (SHR-SP).

anti-aging supplement

This study investigated the effects of astaxanthin on the aortic vessel blood pressure (BP) in relation to endothelium and nitric oxide (NO) to elucidate mechanism and response. The arterial BP in hypertensive rats (N=5-6, p<0.05) fell by almost 10% when they were treated with 50 mg astaxanthin/kg/day for two weeks. Long-term supplementation in SHR-SP rats revealed that 5 mg/kg/day also had the same effect as 50 mg/kg/day (8-9% BP reduction, N=5, p<0.001). At the same time, the control group BP increased by 8% at week 5. Two further studies (N=5-8) by Hussein et al., (2005b and 2006) confirmed this observation by reducing BP almost 16% (p<0.001) at 7 weeks in SHR (Figure 2). Furthermore, astaxanthin had no effect on the normal blood pressure in healthy rats.

Figure 2. Astaxanthin (5mg/kg/day) treated SHR reduced mean blood pressure. ***p<0.001. [Hussein et al., 2005b]

Interestingly, the authors reported a 50% reduction of incidence of stroke in the treated (50 mg/kg/day) SHR-SP group compared to the control group after 14 days. (Hussein et al., 2005a).

In addition, astaxanthin treated mice also showed significant neuroprotective effects at relatively high doses by preventing the ischemia-induced impairment of spatial memory in mice negotiating a water maze (Hussein et al., 2005a). This effect is suggested to be due to the significant antioxidant property of astaxanthin on ischemia-induced free radicals and their consequent pathological cerebral and neural effects. Kudo et al., 2001, also confirmed the neuronal protection of astaxanthin during ischemia in an earlier study.

anti-aging supplement

Mechanism of Anti-hypertension Astaxanthin reduces hypertension

The antihypertensive mechanism may be in part explained by the changes of vascular reactivity and hemorheology.

Figure 3. Astaxanthin (5 mg/kg/day) treated SHR improved blood flow tested by MC-FAN. * p<0.05: ** p<0.01 vs. control. [Hussein et al., 2005b]

Microchannel Array Flow Analysis (MC-FAN) measured a significant increase of blood flow of 11% (Figure 3) in the astaxanthin treated group (N=6-7, p<0.05). Although plasma fluidity is largely influenced by fibrinogen, in this study, the fibrinogen levels did not change and therefore, the improved deformation and reduced blood aggregation are the likely mechanisms (Hussein et al., 2005b). This is supported by Miyawaki et al., (2005) who also used the MC-FAN to demonstrate the significant improvement of blood flow (N=10, p<0.05) in humans treated with 6 mg astaxanthin for 10 days.

Figure 4. Astaxanthin (6mg/day) supplementation for 10 days improves blood flow in humans as tested by MC-FAN *p<0.01 vs. start; #p<0.05 vs. control. [Miyawaki et al., 2005]

A systematic investigation in both relaxant and constrictor responses revealed that astaxanthin can restore the NO dependent relaxation and sensitivity to constriction mechanisms (Figure 5). Astaxanthin reduced sensitivity to angiotensin II (AngII) that is involved in vessel contraction, and scavenged ROS, which would normally hinder nitric oxide (NO) dependent dilation (Hussein et al., 2005b, 2006a, 2006b).

anti-aging supplement

Astaxanthin treatment also maintained the structural composition of the vessel wall structure. Hypertension normally produces thick walled vessels, which alter stiffness and internal volume; thereby reducing volume of blood flow and increasing pressure. Astaxanthin treated rats were protected from such structural changes (Figure 6) as seen in the reduction of the number of branched elastin bands (p<0.001) and improved vessel wall to lumen thickness ratio (p<0.01). Li et al., (2004) substantiated the same structural preservation effect after treating hyperlipidemic rabbits (WHHL) with astaxanthin. The intactness of the internal elastic membranes of aortic segments was an important gauge of atheroma.

Figure 5. Astaxanthin increases relaxant and reduces constrictor mechanisms to help reduce blood pressure in SHR.

Outlook Astaxanthin reduces hypertension

The oxidative status and physiological condition during hypertension are successfully mediated by astaxanthin. The mechanisms of action include improved blood rheology, modulation of constrictor and dilator factors and blood vessel remodeling. Although, these findings are based on spontaneous hypertensive rat models, these serve as a solid basis for extending the hypothesis to human clinical trials.

Figure 6.
A) Coronary artery wall is thinner and lumen is wider in astaxanthin treated rats.
B) Elastin bands are also fewer in number and smoother compared to the control group. [Hussein et al., 2006]

Our Zest for Life vitamin and supplement range
SPECIALTY FORMULAS
CLASSIC VITAMIN RANGE BELOW

adaptogens cope balance not stimulant not sedative

dermaxime anti-aging supplement most advanced dietary way to fight aging

anti-oxidants kills free radicals that can cause premature aging and degenerative diseases

apple cider vinegar capsules

dietary enzymes

hair skin nail boost stong nails glossy hair clear complexion

millennium 2000 weight loss capsule

oystacal calcium supplement better bone density fights osteoporosis

phytosterols phytomedicine plant sterols sterolins

resveratrol alpha lipoic acid anti-oxidant anti-aging

 

vitalyze vitamin B boost capsules

vuka 2000 male sexual supplement

CLASSIC RANGE OF VITAMINS
SPECIALTY FORMULAS ABOVE

vitamin c ascorbic acid

Nutritional information

zest for life vitamin supplements

Underneath we have information page on vitamins, minerals, amino acids, trace elements, enzymes and various nutritional compounds that can impact greatly on your general health, well-being and longevity.

Please note that these pages are for general information only and must not be used to treat or diagnose health concerns.

 
Fat soluble vitamins Trace elements
vitamin ABoron
Vitamin DChromium
Vitamin ECobalt
Vitamin KCopper
Fluorine
Water soluble vitaminsIodine
Vitamin C (Ascorbic acid)Iron
B Complex vitaminsManganese
Vitamin B1 (Thiamine, Thiamin)Molybdenum
Vitamin B2 (Riboflavin)Selenium
Vitamin B3 (Niacin, Niacinamide, Nicotinic Acid)Silicon (Silica)
Vitamin B5 (Pantothenic Acid)Zinc
Vitamin B6 (Pyridoxine)
Vitamin B9 (Folacin, Folic Acid)Enzymes
Vitamin B12 (Cyanocobamin, Cobalamin)Amylase
PABA (Para-AminoBenzoic Acid)Bromelain
CholineCoenzyme Q10
InositolLactase
Vitamin H (Biotin)Lipase
Protease
Amino AcidsMaltase
Alanine
ArginineMiscellaneous nutritional ingredients
AsparagineAdaptogens
Aspartic acidAlpha Lipoic Acid
Branched-Chain Amino AcidsAntioxidants
CarnitineApple Cider Vinegar
CitrullineAstaxanthin
CysteineCreatine
CystineFatty acids
GABA (Gamma-Aminobutyric Acid)Piperine (Pepper extract)
Glutamic acidResveratrol
GlutamineVitamin B13 (Orotic acid)
GlutathioneVitamin B15 (Pangamic Acid)
GlycineVitamin B17 (Laetrile, Amygdalin)
HistidineVitamin F (Fatty Acids)
HydroxyprolineVitamin P (Bioflavonoids)
IsoleucineVitamin T
LeucineVitamin U
Lysine
MethionineHerbal ingredients
NAC (n-Acetyl Cysteine)Echinacea
OrnithineGinger
PhenylalanineGinkgo Biloba
ProlineGinseng
SerineGoldenseal
TaurineGotu Kola (Centella)
ThreonineGrape Seed Extract
TryptophanGreen Tea
TyrosineLicorice
ValineMuira Puama
Olive Leaf Extract
MineralsPhytosterols
CalciumSt John's Wort
ChlorideTribulus Terrestris
Magnesium
PhosphorusWater
PotassiumCarbohydrates
SodiumProtein
SulfurCalories
 
pci dss compliant
website and shopping security
sallamander concepts
Ageless herbal products
Esoteric essential oils
Cellumend anti-cellulite cream
Sanitoets home test kits and testing strips
Zest for Life vitamin supplements
Olinat pure natural facial moisturizing cream
Creme de Vie anti-wrinkle cream

 



Home Products
Ordering in the USA and worldwide Ordering in South Africa
Vitamin encyclopedia Fighting disease with nutrition
RDA Search our site Privacy statement Contact details
 
© Copyright Sallamander Concepts (Pty) Ltd 1998 - 2014


Information contained on this website is for general information purposes only and must not be used to treat or diagnose medical conditions.

All health problems must be referred to a health care professional.

Statements made regarding the products, ingredients and general information have not
been evaluated by the FDA or SAMCC.

No comments must be seen as health claims.

All ingredients used in our products are safe.

None of our ingredients are banned, controlled or restricted in any country.

All products are manufactured in a licensed pharmaceutical laboratory, following strict GMP and ISO standards.


The entire content of this website is copyrighted
This includes text, photographs, logos, metatags etc., and no part whatsoever may be copied or used
privately or for educational purposes, or publishing or for commercial application
without the written permission of Sallamander Concepts (Pty) Ltd.
Using our copyrighted material without permission may result in civil and criminal proceedings.

Our site was last updated on 5 April 2014.