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Serine was first isolated in 1865 from sericin, a silk protein, and is a nonessential amino acid and can be synthesized in the body from glycine.

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Serine is required for the metabolism of fat, tissue growth and the immune system as it assists in the production of immunoglobulins and antibodies. Some derivatives (e.g. ethanolamine) are also important components of the phospholipids found in biological membranes.
It is a constituent of brain proteins and nerve coverings and is also important in the formation of cell membranes, involved in the metabolism of purines and pyrimidines, and muscle synthesis. It is also used in cosmetics as a skin moisturizer.
Although toxicity has not been established it has been found that very elevated serine levels may cause immune suppression and psychological symptoms as in cerebral allergies.
Its production requires adequate amounts of vitamin B3 (niacin), B-6, and folic acid.
It is found in meats and dairy products, wheat gluten, peanuts as well as soy products.
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